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For an excellent full text review of this anatomy and circuits for touch sensing, please see: Thank you to our sponsors AG1 (Athletic Greens): InsideTracker: Thesis: Supplements from Momentous For the full show notes, visit hubermanlab.com Timestamps (00:00:00) Skin, Pain, Pleasure (00:01:50) Protocol 1: Maximizing Motivation (with Dopamine & Pleasure) (00:07:12) Sponsors (00:12:04) Pleasure & Pain, & Skin Sensors (00:18:13) Sensing Touch with Your Brain: Magnification of Feet, Hands, Lips, Face, Genitals (00:22:16) Two-Point Discrimination, Dermatomes (00:28:11) Thoughts & Genes That Make Physical Pain Worse (00:33:45) Expectations, Anxiety, & Pain Threshold (00:40:27) Protocol 2: Cold Sensing Is Relative
Nearly every microgram you inject reaches systemic circulation
The verification checklist above - named pharmacy, verifiable license, certificate of analysis option, exact dosing instructions reviewed before first injection, care team contact information confirmed before you need it - exists because these are the documented points of failure
allowing the medication to reach room temperature can reduce discomfort, but do not artificially warm devices